Courtney Henggeler (Missy Cooper)
Missy is Sheldon’s twin sister, but she’s also his complete opposite. She’s a charming social butterfly, and when she comes to visit, she makes Leonard, Howard, and Raj fight over who gets to date her. They all try to make their advancements, but they strike out one by one.
Courtney Henggeler, who plays Missy, is currently starring in the YouTube Premium show Cobra Kai, based on The Karate Kid movie series, alongside Ralph Macchio and William Zabka. And in real life, she’s just as stunning as she is on-screen.
Laura Spencer (Emily Sweeney)
Aarti Mann (Priya Koothrappali)
While Raj is dating his girlfriend Emily, he meets a cool artist named Claire at the comic book store. Raj is immediately taken with her and begins to pursue her, even though he’s already dating Emily. After dating both of them at the same time, he eventually ends it with both of them and remains alone (hey, that’s what you get for playing the field).
Alessandra is known for playing Zoe on the sci-fi drama Caprica. She was also featured as a Maxim girl – and we totally understand why.
Alessandra Torresani (Claire)
Sara Rue (Stephanie Barnett)
Sara Rue plays Dr. Stephanie Barnett, one of Leonard’s girlfriends on the show. While she initially goes on a date with Howard, she ends up dating Leonard, which causes a temporary tear in Leonard and Howard’s relationship.
But when she promises to introduce Howard with one of her girlfriends, he immediately forgives everything. Sara played roles in shows like teen dramedy Popular and the sitcom Less than Perfect. And judging by her Instagram page, she’s as fashionable as she is gorgeous.
April Bowlby (Rebecca)
Sara Gilbert (Leslie Winkle)
Sara Gilbert used to play opposite Johnny Galecki (who plays Leonard) in the sitcom Roseanne. The two also dated in real life, so the fans were excited to see her get a role on The Big Bang Theory. On the show she plays Leslie Winkle, a pragmatic scientist working with the guys in Caltech.
She dates both Leonard and Howard on the show, but both of these brief relationships end. Sara is also the creator and host of the CBS talk show The Talk.
Margo Harshman (Alex Jensen)
Valerie Azlynn (Alicia)
Alicia is a new neighbor who moves into the upstairs apartment of Leonard and Sheldon’s building. Like Penny, she’s charismatic and attractive, so she immediately gets the boys undivided attention.
Penny, who is already used to being the center of the group, becomes extremely jealous of Alicia, and resents the way she gets the boys to do things for her. Like on the show, Valerie Azlynn is a real stunner, but she seems much nicer than the character she plays.
Christine Baranski (Dr. Beverly Hofstadter)
Charlotte Newhouse (Joy)
Charlotte Newhouse appears on the show as Joy, a woman who is set up with Leonard on a blind date by Howard and Bernadette. She’s a fitness-crazed woman who shows up at the restaurant wearing workout clothes, and behaves very crassly.
Leonard doesn’t enjoy the date at all, but still agrees to go with her to a wedding when she says there maybe something in it for him. Charlotte Newhouse also plays Billie on the comedy Idiotsitter, and seems much lovelier in real life than Leonard’s date.
Riki Lindhome (Ramona Nowitzki)
Brooke D’Orsay (Christy Vanderbilt)
Played by Brooke D’Orsay, Christy is Penny’s friend from Nebraska who comes into town. Penny lets her stay in her apartment, but she overstays her welcome when she starts dating Howard, and the two take over Penny’s apartment. She makes Howard buy her things, which eventually leads his mother to threaten to cut him off of the inheritance if he continues dating her.
Like April Bowlby, she was also on Two and a Half Men and the dramedy Drop Dead Diva. And doesn’t she look lovely in this picture?
Eliza Dushku (Angela Page)
Laurie Metcalf (Mary Cooper)
Mary Cooper, played by actress Laurie Metcalf, is Sheldon’s pious and stern mother. The complete opposite of Leonard’s mother, Mary is nurturing and loving, and knows how to put her son in his place for his own good.
She’s not always politically correct, and often relies on silly superstitions, but viewers fell in love with her as soon as she appeared. Mary is an elegant woman, but in reality Laurie has a certain glam that only adds to her beauty.
Kate Micucci (Lucy)
Alice Amter (Mrs. Koothrappali)
You might only know her as an image on a screen, but Raj’s mother provides a great comical relief to the show. Raj often talks to his parents on video calls, which are usually hilarious.
Eventually, his parents get divorced, and Raj plays both of them in order to get more money and luxurious things out of his rich parents. In real life, Alice Amter who plays the character looks totally different than Mrs. Koothrappali, and we’re loving her style.
Becky O’Donohue (Siri)
Megan Heyn (Natalie)
Megan Heyn appears in a Big Bang Theory episode where Stuart is having trouble getting attractive women to come to his comic book store. Penny and Bernadette help him out in that regard, helping out his confidence in the process.
In an episode that centers around stunning women, it is fitting that Megan is introduced, for obvious reasons. She portrays the role of Natalie, and although her role was minor, her impact wasn’t forgotten.
Kelli Goss (Chelsea)
Morgan Hewitt (Lizzy)
When you gaze upon the picture of the lovely young Morgan Hewitt, you might have trouble wondering why she only appeared in one Big Bang Theory episode – “The Itchy Brain Stimulation,” from season eight. We have no doubt in our minds that fans of the show would’ve been very pleased to see more of sweet Liz (the character she played), but what can you do.
In addition to acting, Morgan is a very successful model.
Courtney Ford (Alice)
Analeigh Tipton (Vanessa Bennet)
Analeigh Tipton appears twice on the on the Big Bang Theory. First as herself, where she is a contestant on America’s Next Top Model (because this was the case in real life).
Years later, she appeared as Vanessa, a mysteriously intelligent woman who solves Sheldon’s intricate scavenger hunt, knocking on his door and causing him to wonder if he’d met his match. In both of these appearances, you can bet your bottom dollar that viewers at home were quite pleased.
Katie Leclerc (Emily)
Lauren Lapkus (Denise)
We all love Stuart on the Big Bang Theory, for his awkwardness and his endearing hopelessness. And yet it’s almost perfect when he finds an assistant named Denise that converses with him well, played by the talented Lauren Lapkus.
She works at his comic store for a little while, which is appropriate because she is a total comic book nerd as well. As far as Lauren, you may recognize her from Jurassic World, a thriller which she has recently appeared in.
Beth Behrs (Nell)
Elizabeth Bogush (Dr. Catherine Millstone)
Dr. Catherine Millstone is gets hired by Dr. Laughlin in an episode called “The Pirate Solution,” which took place in the third season.
Played by the lovely Elizabeth Bogush, Raj is originally expected to work with the both of them. The problem is that Raj is still unable to talk to women unless he’s intoxicated, so he gets drunk when he sees her. This leads to him making an inappropriate comment, which she eventually files a complaint about.
Danica McKellar (Abby)
Katee Sackhoff (as herself)
Katee Sackhoff appears as herself in a make-believe daydream that Howard is imagining for himself.
One of the most common themes we find ourselves witnessing in the Big Bang Theory is fantasy, and given that our main characters love comics and science fiction, it stands to make sense that Howard would think of Sackhoff – who is known for her portrayal of Lieutenant Kara “Starbuck” Thrace on the hit sci fi show Battlestar Galactica.
Emma Degerstedt (Emma)
Samantha Potter (as herself)
Samantha Potter is an actress and a model who used to be on America’s Next Top Model. We see her because Sheldon, Leonard, and the crew, are big fans of the show America’s Next Top Model.
But after they lose Wifi, they decide that they would rather meet the models in person. Somehow, they manage to track down the house where they all live together, and drive all the way there and meet them in person.
Tania Raymonde (Yvette)
Summer Glau (as herself)
It’s one thing to strike up a conversation with a random girl on a train, but it’s another thing to initiate a conversation with your favorite sci-fi actress. It’s no easy task at all, but Leonard, Raj, and the boys do it anyway while they are on a long train ride, and they notice Summer Glau is actually sitting there in a nearby booth.
Of course, the Firefly star is very amused by the antics of the boys – even as they strike out one by one.
Jodi Lyn O’Keefe (Mikayla)
Judy Greer (Dr. Elizabeth Plimpton)
We’re guessing that you must have seen Judy Greer before, because she’s an actress who’s appeared in countless other places on screen, such as Jurassic World, and the TV show Two and a Half Men. In the Big Bang Theory, she plays the role of Dr.
Elizabeth Plimpton, a brilliant scientist who even Sheldon is impressed by. She is very forward from a romantic standpoint, making advances to all the boys, and eventually gets together intimately with Raj.
Rachel Cannon (Patty)
Sarah Buehler (Sarah)
The Big Bang Theory is a show that is known for its ability to stick with a concurrent theme, while still exploring a wide range of genres and topics. One of these themes is the style of goth, and this is when we meet a young woman by the name of Sarah.
We see her in an episode called “The Gothowitz Deviation,” and her catchphrase is “not that anyone cares.” For the brief time she’s on the show, she certainly gets a fair share of laughs.
Ally Maki (Joyce Kim)
Sara Erikson (Gwen)
When Penny starts working as a pharmaceutical sales rep, she meets all kinds of new people. But there was one scene where she runs into a couple of old friends from her acting days, and one of these friends is Gwen, played by Sara Erikson.
Although Penny doesn’t seem too happy about her current job, Gwen comforts her by saying that she heard it pays “good money.” Nothing like an old friend to raise your spirits by giving some outside perspective.
Maria Canals-Barrera (Issabella)
Sarayu Blue (Lalita Gupta)
If you’re someone who’s familiar with the earlier seasons of the Big Bang Theory, you’ll recognize this Sarayu Blue, who portrayed Lalita Gupta in the first season. A childhood friend of Raj’s, she is seen attempting to date him until he ruins it by getting hammered on the outing.
She later takes a liking to Sheldon, who tells her that she reminds him of a princess. Sarayu is best known for her portrayal of Angela on the Fox sitcom Sons of Tucson.
Tiffany Dupont (Angela)
Ashley Austin Morris (Laura)
Ashley Austin Morris plays the role of Laura, a young woman who manages to spark a solid amount of jealousy in the heart of Penny, when she sees Leonard flirting with her. After Leonard feels under-appreciated by Penny at a bar, he decides to introduce himself to Laura, and begins to lie about many things about himself.
Penny ends up coming over and spills the beans on Leonard, at which point Leonard accuses Penny of being hypocritical.
Sierra Edwards (Escort girl)
Regina King (Janine Davis)
A prominent actress in Hollywood, Regina King appeared in a total of five Big Bang Theory episodes, which is actually a lot more than we can say for a lot of girls on this list. She plays the role of Janine Davis, Caltech’s Human Resources administrator, and she certainly has her share of awkward run ins with Sheldon and the crew.
One of these cringeworthy moments is when Howard is sent to her office for making inappropriate comments about intimacy.
Swati Kapila (Ruchi)
Erin Allin O’Reilly (Cheryl)
Cheryl is a waitress who Penny works with at the Cheesecake Factory, and she’s an active participant in a number of solid comedic moments. One of these moments is when she meets Raj at a Halloween party that Penny throws.
She later gets together with him romantically after calling him a “good listener,” not realizing that Raj is unable to speak to women. Portrayed by the lovely Erin Allin O’Reilly, she has also appeared in the comedy film, Dumb and Dumber To.
Kaley Cuoco (Penny Hofstadter)
Melissa Rauch (Bernadette Wolowitz)
Everyone loves the sweet and spunky Bernadette on The Big Bang Theory, who’s been a fan-favorite ever since she joined the show. She starts out as a timid waitress and Microbiology student who dates Howard Wolowitz, and slowly comes to her own working at a pharmaceutical company. Bernadette is absolutely adorable, thanks to her high-pitched voice and always rocking a pretty dress.
Melissa Rauch, who plays Bernadette on the series, seems to have more of an edge on her Instagram account. She’s definitely not afraid to dress up in glamorous dresses and show off her spunky attitude. And she’s certainly looking sizzling in the picture below, in a dark purple dress and high heels.