Celebrities and Their BFFs

Matt Damon and Ben Affleck

A list of celebrity BFFs. The following celebrities are best friends in real life, and they give new meaning to the term "Hollywood power couple." Like most relationships under the spotlight, famous friendships come and go in show business.

However, the duos in this celeb BFF gallery have a close bond and are supportive of each other's careers as well as their personal lives.

  BFFs Ben Affleck and Matt Damon may have one of Hollywood's best and most enduring friendships.

Jennifer Aniston and Courteney Cox

Growing up together, they achieved Oscars success with Good Will Hunting in 1997, and have continued to stay close over the years.

George Clooney and Brad Pitt

  Courteney Cox and Jennifer Aniston's friendship kicked off in the '90s when they worked on Friends, which saw the actresses take on polar opposite, yet equally lovable, roles.

Tina Fey and Amy Poehler

  Long before they were married dudes careening down the far side of the over-50 hill, Brad Pitt and George Clooney were single guys, threesoming their way up the other side of that hill.

  Amy and Tina met at Chicago's ImprovOlympic when owner Charna Halpern recognized similarities in the two young performers.

Justin Timberlake and Jimmy Fallon

Since then, they were best friends.

  It's no secret that Jimmy Fallon and Justin Timberlake are close.

Leonardo DiCaprio and Tobey Maguire

They sing, they dance, and they get a lot of laughs together.

  Leonardo DiCaprio and Tobey Maguire share the big screen as pals Jay Gatsby and Nick Carraway in The Great Gatsby, which hit theaters last week and premiered at the Cannes Film Festival on Wednesday, but their real-life relationship started long ago.

Drew Barrymore and Cameron Diaz

Leo and Tobey have been friends for 25 years, after meeting at an audition in the late '80

  If Drew Barrymore ever runs into trouble, she says she can count on bestie Cameron Diaz to be the one to help her out.

Penélope Cruz and Salma Hayek

Thats what I call true friendship.

  Spanish-speaking duo Salma Hayek and Penélope Cruz celebrated their long-standing friendship on Tuesday by posing for selfies together. The Mexican-born 50-year-old - who boasts 3M followers - captioned the BFF snap: 'Good friends are forever Los buenos amigos son para siempre.

Vanessa Hudgens and Ashley Tisdale

spain mexico.'

Kate Winslet and Reese Witherspoon

  Vanessa Hudgens and Ashley Tisdale have been the definition of friendship goals for the past 11 years, since fans first fell in love with High School Musical's sweet Gabriella Montez and sassy Sharpay Evans.

  Reese Witherspoon explains her friendship with Kate Winslet best: "Imagine my good fortune when Kate Winslet moved into my neighborhood, rang my door bell and said, 'Dahling Sam is off shooting, and I believe our children are the same age.

Will Ferrell and John C. Reilly

Could they possibly have a play date and oh, by the way, it's almost 9 o'clock and I've had nothing to drink, do you have any wine?

  Long before the two funnymen co-starred in "Talladega Nights," they were just two super-famous guys hanging out. As for why the two are so tight, the "Wreck-It Ralph" star sings Will Ferrell's praises, saying, "We just really hit it off. I feel like I've known him since we were kids.

Jessica Biel and Jennifer Garner

There are a lot of comedians who are very dark and competitive, but he's not like that at all. He's just a very decent guy."

  Jennifer Garner and Jessica Biel barely knew each other before starring together in this year's Valentine's Day.

Nicole Kidman and Naomi Watts

But the actresses hit it off immediately, and they've even been touted as the new "Laverne & Shirley" by their other co-stars.

  Naomi Watts and Nicole Kidman aren't just fellow Aussie actresses; they're also best friends. The ladies have been close since attending high school at the Phillip Street Theatre in Sydney, and their friendship is evident at movie premieres and award shows to this day.

Natalie Portman and Rashida Jones

In 1991, they starred together in the Australian independent film Flirting.

  Natalie Portman knows she can rely on fellow starlet and longtime friend Rashida Jones. She said of her pal, "She would fight beasts 10 times her size to protect the people she loves.

Liv Tyler and Kate Hudson

She is the kind of friend who can sub in and love you through the times when you can't necessarily love yourself."